Fifa president Sepp Blatter and Uefa boss Michel Platini have been suspended for eight years from all football-related activities following an ethics investigation.
The bans come into force immediately.
At 79, Blatter’s suspension effectively ends his long career as a football administrator.
Fifa boss since 1998, the Swiss had already announced his intention to stand down before February’s presidential election.
Platini, 60, was tipped as a future leader of football’s world governing body and had hoped to succeed Blatter.
A three-time European Footballer of the Year and former captain of France, he had been in charge of Uefa since 2007.
Blatter and Platini were found guilty of ethics code breaches surrounding a £1.3m ($1.94m) “disloyal payment” made to the Frenchman in 2011.
Both men denied any wrongdoing and claimed the payment was honouring an agreement made in 1998 for work carried out between 1998 and 2002 when Platini worked as a technical adviser for Blatter.
The payment was not part of Platini’s written contract but the pair have insisted that it was a verbal agreement which is legal under Swiss law.
German judge Hans-Joachim Eckert, the chairman of Fifa’s adjudicatory chamber, held disciplinary hearings for the pair last week.
Charges included conflict of interest, false accounting and non co-operation, with investigators submitting a file of more than 50 pages.